Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure
نویسندگان
چکیده
منابع مشابه
Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure.
Considerable work is being carried out on endometrial NK cells to determine whether they play a role in successful pregnancy outcome. In addition there is debate about whether measurements of uNK should be included in the clinical assessment for women with recurrent implantation failure or recurrent miscarriage. A hindrance to taking this forward is the fact that the density of uNK cells report...
متن کاملO-167 Standardisation of uterine natural killer (uNK) cell measurements in endometrium of women with recurrent miscarriage
Study question: Can assessment of density of uterine natural killer (uNK) cells be standardised across different research laboratories? Summary answer: Analysis of the same fifteen sections in three different centres showed variation which could be attributed to tissue processing, image capture, where in the tissue sample assessment images were taken and what was counted as an immunopositive ce...
متن کاملUterine natural killer cells and angiogenesis in recurrent reproductive failure.
BACKGROUND Increased numbers of phenotypically unusual CD56(bright) CD16- uterine natural killer (uNK) cells have been associated with recurrent reproductive failure. uNK cells produce angiogenic growth factors and are potential regulators of decidual angiogenesis in early pregnancy. The final common mechanism for early pregnancy loss is thought to be early onset of the maternal circulation and...
متن کاملPrognostic value of the measurement of uterine natural killer cells in the endometrium of women with recurrent miscarriage.
BACKGROUND Studies in mice suggest that CD56 + uterine natural killer (uNK) cells play an important role in implantation. Studies in humans have described an increase in the number of uNK cells in the non-pregnant mid-secretory endometrium of women with unexplained recurrent miscarriage (RM). However, the predictive value of uNK cell number in the maintenance of pregnancy is controversial. ME...
متن کاملThe State of Peripheral Blood Natural Killer Cells and Cytotoxicity in Women with Recurrent Pregnancy Loss and Unexplained Infertility
Objective : The prognostic value of peripheral natural killer (pNK) cells, as a screening test in women with recurrent pregnancy loss (RPL) and unexplained infertility is still a matter for discussion. The aim of this study was to compare the percentage of circulating CD56+NK cells, CD69 and perforin markers between women with unexplained infertility and RPL with healthy control group. Material...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Reproductive Immunology
سال: 2016
ISSN: 0165-0378
DOI: 10.1016/j.jri.2016.04.290